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Phospho-BTK/ITK (Y551/Y511) Mouse anti-Human, Mouse, Clone: M4G3LN, eBioscience™

Mouse Monoclonal Antibody

$216.05 - $506.05

Specifications

Antigen Phospho-BTK/ITK (Y551/Y511)
Clone M4G3LN
Host Species Murine
Gene Alias Bruton’s tyrosine kinase (Btk), agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase/IL-2 inducible T-cell kinase (Itk), T-cell-specific kinase, Tyrosine-protein kinase Lyk
Species Reactivity Human, Mouse
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Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122747 Life Technologies
LS14901580
25μg Each for $216.05
501129061 Life Technologies
LS14901582
100μg Each for $506.05
Specifications

Description

This M4G3LN monoclonal antibody recognizes human and mouse Bruton’s tyrosine kinase (also known as BTK, agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase)/interleukin-2-inducible tyrosine kinase (also known as ITK, T-cell-specific kinase, Tyrosine-protein kinase Lyk) when phosphorylated on Y551 and Y511, respectively.

In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family. The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180. Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively. People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency.

Specificity of this M4G3LN clone was determined by ELISA, flow cytometry, and western blotting.
Description & Specifications

Specifications

Phospho-BTK/ITK (Y551/Y511)
Murine
Human, Mouse
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
M4G3LN
Bruton’s tyrosine kinase (Btk), agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase/IL-2 inducible T-cell kinase (Itk), T-cell-specific kinase, Tyrosine-protein kinase Lyk
Flow Cytometry (Intracellular Staining),Immunohistochemistry (Formalin/Paraffin),Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL