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Phospho-ATM (S1981) Mouse, Clone: 10H11.E12, eBioscience™

Mouse Monoclonal Antibody

$133.32 - $335.28

Specifications

Antigen Phospho-ATM (S1981)
Clone 10H11.E12
Host Species Murine
Gene Alias Ataxia-telangiectasia mutated
Applications Flow Cytometry (Intracellular Staining),Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Immunoprecipitation,Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122751 Life Technologies
LS14904680
25μg Each for $133.32
501122752 Life Technologies
LS14904682
100μg Each for $335.28
Specifications

Description

This 10H11.E12 monoclonal antibody recognizes the human, mouse, and rat ataxia-telangiectasia (ATM) protein when phosphorylated on serine 1981. ATM belongs to the family of PI3 kinases and functions by coordinating cell cycle arrest and initiation of DNA repair through the phosphorylation of a multitude of substrates in response to DNA damage and oxidative stress. ATM exists as dimers or multimers in its inactive state but in response to DNA breaks, becomes activated through formation of monomers and autophosphorylation. Activated ATM is recruited to the site of DNA double strand breaks where it halts the cell cycle and initiates DNA repair through the phosphorylation of downstream DNA damage response pathway members. Loss of functional activity of ATM results in ataxia-telangiectasia (AT), a disease characterized by early onset neurodegeneration and predisposition to cancer. AT patients are immunodeficient, radiosensitive, and have an increased risk of certain cancer types such as lymphoma and leukemia.
Description & Specifications

Specifications

Phospho-ATM (S1981)
Murine
Flow Cytometry (Intracellular Staining),Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Immunoprecipitation,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
10H11.E12
Ataxia-telangiectasia mutated
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer