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phospho-AKT Mouse, FITC, Clone: SDRNR, eBioscience™

Mouse Monoclonal Antibody

$157.08 - $407.88

Specifications

Antigen phospho-AKT
Clone SDRNR
Host Species Murine
Gene Alias Protein Kinase B (PKB)
Applications Flow Cytometry (Intracellular Staining)
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122182 Life Technologies
LS11971541
25 Tests Each for $157.08
501122183 Life Technologies
LS11971542
100 Tests Each for $407.88
Specifications

Description

This SDRNR monoclonal antibody recognizes human and mouse AKT (also known as Protein Kinase B (PKB)) when phosphorylated on S473. AKT is a serine/threonine protein kinase that plays a key role in multiple cellular processes including metabolism, proliferation, apoptosis/survival, and migration. There are three homologous isoforms of AKT: AKT1, AKT2, and AKT3. AKT is activated by binding of its pleckstrin homology (PH) domain to membrane phospholipids and by phosphorylation. Phosphorylation of AKT at T308 by PDK1 and at S473 is required for full activation of this kinase. AKT promotes cell survival by inhibiting apoptosis via phosphorylation and inactivation of several targets including Bad, Foxo1, c-Raf, and caspase-9. Deregulation of AKT has been implicated as a major contributing factor in many types of cancer. AKT is negatively regulated by the phosphatase PTEN as well as by the chemical inhibitor LY294002. Specificity of this SDRNR clone was determined by ELISA, flow cytometry, and western blotting.
Description & Specifications

Specifications

phospho-AKT
Murine
Flow Cytometry (Intracellular Staining)
FITC
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.06μg)/test
SDRNR
Protein Kinase B (PKB)
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer