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phospho-AKT Mouse, FITC, Clone: SDRNR, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $448.05

Specifications

Antigen phospho-AKT
Clone SDRNR
Host Species Mouse
Gene Alias Protein Kinase B (PKB)
Species Reactivity Human , Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122182

 
affymetrix
11971541
25 tests Each for $172.55

501122183

 
affymetrix
11971542
100 tests Each for $448.05
Description & Specifications

Specifications

Antigen phospho-AKT
Clone SDRNR
Host Species Mouse
Gene Alias Protein Kinase B (PKB)
Species Reactivity Human , Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate FITC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.06μg)/test

This SDRNR monoclonal antibody recognizes human and mouse AKT (also known as Protein Kinase B (PKB)) when phosphorylated on S473. AKT is a serine/threonine protein kinase that plays a key role in multiple cellular processes including metabolism, proliferation, apoptosis/survival, and migration. There are three homologous isoforms of AKT: AKT1, AKT2, and AKT3. AKT is activated by binding of its pleckstrin homology (PH) domain to membrane phospholipids and by phosphorylation. Phosphorylation of AKT at T308 by PDK1 and at S473 is required for full activation of this kinase. AKT promotes cell survival by inhibiting apoptosis via phosphorylation and inactivation of several targets including Bad, Foxo1, c-Raf, and caspase-9. Deregulation of AKT has been implicated as a major contributing factor in many types of cancer. AKT is negatively regulated by the phosphatase PTEN as well as by the chemical inhibitor LY294002. Specificity of this SDRNR clone was determined by ELISA, flow cytometry, and western blotting.