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Phospho-4E-BP1 (T36/T45) Mouse anti-Human, Mouse, eFluor 660, Clone: V3NTY24, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $506.05

Specifications

Antigen Phospho-4E-BP1 (T36/T45)
Clone V3NTY24
Host Species Mouse
Species Reactivity Human, Mouse
Applications Flow Cytometry (Intracellular Staining)
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124494

 
affymetrix
50910742
100 tests Each for $506.05

501124493

 
affymetrix
50910741
25 tests Each for $201.55
Description & Specifications

Specifications

Antigen Phospho-4E-BP1 (T36/T45)
Clone V3NTY24
Host Species Mouse
Species Reactivity Human, Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.06μg)/test

The V3NTY24 monoclonal antibody recognizes human and mouse eukaryotic translation initiation factor eIF4E-binding protein 1 (4E-BP1) when phosphorylated at threonine 37 and/or threonine 46. 4E-BP1 is a member of a family of translation repressor proteins that include 4E-BP2 and 4E-BP3. In its non-phosphorylated form, 4E-BP1 binds to the eIF4E translation initiation factor and represses cap-dependent translation. Phosphorylation of 4E-BP1 at multiple sites is necessary to disrupt this interaction and de-repress cap-dependent translation. Studies have identified several kinases that phosphorylate 4E-BP1. For instance, FRAP/mTOR phosphorylates Thr37 and Thr46, while ATM phosphorylates Ser111. Phosphorylation of 4E-BP1 at Thr37 and Thr46 is inhibited by the PI3 kinase inhibitors LY294002 and wortmannin.