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Alfa Aesar™ Phorbol 12-myristate 13-acetate, 99+%

Activates protein kinase C and promotes skin tumors in mice

Chemical Identifiers

Chemical Name or Material Phorbol 12-myristate 13-acetate
CAS 16561-29-8
Molecular Formula C36H56O8
Formula Weight 616.83
MDL Number MFCD00036736
Beilstein 2407201
Merck Index 14,7332
Synonym PMA; TPA
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAJ63916LB0

  SDS
alfa aesar™
J63916LB0
5mg CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

AAJ63916MCR

  SDS
alfa aesar™
J63916MCR
1mg CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Description & Specifications

Specifications

Formula Weight 616.83
Chemical Name or Material Phorbol 12-myristate 13-acetate
MDL Number MFCD00036736
CAS 16561-29-8
Physical Form Film or Powder
Assay ≥99%
Molecular Formula C36H56O8
Beilstein 2407201
Merck Index 14,7332
Synonym PMA; TPA
Health Hazard 1 Warning
Health Hazard 2 GHS H Statement
H315
Causes skin irritation.
Health Hazard 3 GHS P Statement
P280-P264-P362-P321-P332+P313-P302+P352
Wear protective gloves/protective clothing/eye protection/face protection.
Wash thoroughly after handling.
Take off contaminated clothing and wash before reuse.
Specific treatment (see label).
If skin irritation occurs: Get medical advice/attention.
IF ON SKIN: Wash with plenty of soap and water.
RTECS Number QH4377000
Recommended Storage −30° to −10°C
Sensitivity Light Sensitive
Color White
Quantity 5mg

Applications
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.

Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Safety and Handling

Warning

GHS P Statement
P280-P264-P362-P321-P332+P313-P302+P352
Wear protective gloves/protective clothing/eye protection/face protection.
Wash thoroughly after handling.
Take off contaminated clothing and wash before reuse.
Specific treatment (see label).
If skin irritation occurs: Get medical advice/attention.
IF ON SKIN: Wash with plenty of soap and water.

GHS H Statement
H315
Causes skin irritation.

−30° to −10°C