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Alfa Aesar™ Phorbol 12-myristate 13-acetate, 99+%

Activates protein kinase C and promotes skin tumors in mice

Manufacturer:  Alfa Aesar™ J63916MB

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Catalog No. AAJ63916MB



Description

Description

Applications
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.

Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
Specifications

Specifications

Phorbol 12-myristate 13-acetate
White
16561-29-8
MFCD00036736
14,7332
PHEDXBVPIONUQT-RGYGYFBISA-N
616.836
CHEBI:37537
Film or Powder
Light Sensitive
25mg
C36H56O8
2407201
phorbol 12-myristate 13-acetate, phorbol ester, 12-o-tetradecanoylphorbol-13-acetate, 12-o-tetradecanoylphorbol 13-acetate, factor a1, tetradecanoylphorbol acetate, 12-tetradecanoylphorbol 13-acetate, factor a1 croton oil, phorbol 13-acetate 12-myristate, phorbol-12-myristate-13-acetate
CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
27924
616.83
≥99%

Chemical Identifiers

16561-29-8
616.836
PHEDXBVPIONUQT-RGYGYFBISA-N
27924
CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
C36H56O8
MFCD00036736
phorbol 12-myristate 13-acetate, phorbol ester, 12-o-tetradecanoylphorbol-13-acetate, 12-o-tetradecanoylphorbol 13-acetate, factor a1, tetradecanoylphorbol acetate, 12-tetradecanoylphorbol 13-acetate, factor a1 croton oil, phorbol 13-acetate 12-myristate, phorbol-12-myristate-13-acetate
CHEBI:37537
Safety and Handling

Safety and Handling

GHS H Statement
H315
Causes skin irritation.

GHS P Statement
P280-P264-P362-P321-P332+P313-P302+P352
Wear protective gloves/protective clothing/eye protection/face protection.
Wash thoroughly after handling.
Take off contaminated clothing and wash before reuse.
Specific treatment (see label).
If skin irritation occurs: Get medical advice/attention.
IF ON SKIN: Wash with plenty of soap and water.

Warning

RTECSNumber : QH4377000

Recommended Storage : −30° to −10°C

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