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Phorbol 12-myristate 13-acetate, 95%, Thermo Scientific Chemicals
Activates protein kinase C and promotes skin tumors in mice
Supplier: Thermo Scientific Chemicals J63916MA
Description
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsPMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Solubility
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Notes
Light Sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
Specifications
| Phorbol 12-myristate 13-acetate | |
| White | |
| MFCD00036736 | |
| 2407201 | |
| 14,7332 | |
| Very soluble in methanol,soluble in DMSO,chloroform,ethanol or acetone,ether,ethyl acetate,DMF or acetonitrile. Insoluble in water. | |
| CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O | |
| 616.84 | |
| CHEBI:37537 | |
| ≥99% |
| 16561-29-8 | |
| C36H56O8 | |
| 10 mg | |
| Light sensitive | |
| phorbol 12-myristate 13-acetate, phorbol ester, 12-o-tetradecanoylphorbol-13-acetate, 12-o-tetradecanoylphorbol 13-acetate, factor a1, tetradecanoylphorbol acetate, 12-tetradecanoylphorbol 13-acetate, factor a1 croton oil, phorbol 13-acetate 12-myristate, phorbol-12-myristate-13-acetate | |
| PHEDXBVPIONUQT-RGYGYFBISA-N | |
| (1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,â¶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate | |
| 27924 | |
| 616.83 | |
| Film or Powder |
Chemical Identifiers
| 16561-29-8 | |
| 616.84 | |
| PHEDXBVPIONUQT-RGYGYFBISA-N | |
| 27924 | |
| (1S,2S,6R,10S,11R,13S,14R,15R)-13-(acetyloxy)-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxotetracyclo[8.5.0.0²,â¶.0¹¹,¹³]pentadeca-3,8-dien-14-yl tetradecanoate |
| C36H56O8 | |
| MFCD00036736 | |
| phorbol 12-myristate 13-acetate, phorbol ester, 12-o-tetradecanoylphorbol-13-acetate, 12-o-tetradecanoylphorbol 13-acetate, factor a1, tetradecanoylphorbol acetate, 12-tetradecanoylphorbol 13-acetate, factor a1 croton oil, phorbol 13-acetate 12-myristate, phorbol-12-myristate-13-acetate | |
| CHEBI:37537 | |
| CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O |
Safety and Handling
GHS H Statement
H315
Causes skin irritation.
P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
H315-H319-H335
RTECSNumber : QH4377000
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only