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Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered

Catalog No. AAJ670278EQ
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Catalog No. AAJ670278EQ Supplier Thermo Scientific Chemicals Supplier No. J670278EQ

Description

Phleomycin (zeomycin), CAS # 11006-33-0, is a broad-spectrum antibiotic that acts by intercalating DNA and inducing double-stranded breaks. | CAS: 11006-33-0 | C51H75N17O21S2 | 1326.379 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Phleomycin is a glycopeptide broad-spectrum antibiotic from the bleomycin family
  • Phleomycin ntercalates DNA, producing double-stranded breaks and preventing cell division

Application

  • Phleomycin can chelate some active metals
  • Phleomycin is appropriate for the laboratory study of antibiotic resistance and mechanisms of DNA interactions

Chemical Identifiers

CAS 11006-33-0
Molecular Formula C51H75N17O21S2
Molecular Weight (g/mol) 1326.379
MDL Number MFCD00131846
InChI Key QRBLKGHRWFGINE-UGWAGOLRSA-N
PubChem CID 72511
IUPAC Name 2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)-
SMILES CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)(C)OC4C(C(C(C(O4)CO)O)(C(=O)N)O)O)C(=O)NC(C)C(C(C)C(=O)NC(C(=O)C)C(=O)NCCC5=NC(CS5)C6=NC(=CS6)C(=O)N)O

Specifications

Type Phleomycin
Physical Form Liquid
Concentration 20mg/mL in distilled water
Quantity 5 x 1 mL
Chemical Name or Material Phleomycin, sterile-filtered

Safety and Handling

Hazard Category H317-H351
Hazard Statement GHS H Statement
H341
Suspected of causing genetic defects.
Precautionary Statement P201-P202-P261-P272-P280g-P281-P302+P352-P308+P313-P333+P313-P363-P501c
RTECSNumber SY0525000
TSCA No
storageNote1 −30° to −10°C
Recommended Storage Store at -20°C

RUO – Research Use Only