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Thermo Scientific™ Lab Vision™ Pds1 Ab-1, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ Pds1 Ab-1, Mouse Monoclonal Antibody.

$257.88 - $1,312.61

Specifications

Antigen Pds1 Ab-1
Clone DCS-280
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Applications Immunohistochemistry (Paraffin)
View More Specs
Products
Catalog Number Mfr. No. Formulation Quantity Price Quantity    

MS1511P

 
thermo scientific™ lab vision™
MS-1511-P
Purified Ab with BSA and Azide 1mL Each for $1,208.02

MS1511P0

 
thermo scientific™ lab vision™
MS-1511-P0
Purified Ab with BSA and Azide 100µL Each for $257.88

MS1511P1

 
thermo scientific™ lab vision™
MS-1511-P1
Purified Ab with BSA and Azide 500µL Each for $715.55

MS1511P1ABX

 
thermo scientific™ lab vision™
MS1511P1ABX
Ab without BSA/Azide (Frozen) 100µL Each for $789.76

MS1511PABX

 
thermo scientific™ lab vision™
MS1511PABX
Ab without BSA/Azide (Frozen) 200µL Each for $1,312.61

MS1511R7

 
thermo scientific™ lab vision™
MS-1511-R7
Ready-to-use for IHC (UVLP) 7mL Each for $624.71
Description & Specifications

Specifications

Antigen Pds1 Ab-1
Clone DCS-280
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Applications Immunohistochemistry (Paraffin)
Applications Western Blotting
Classification Monoclonal
Conjugate Unlabeled
Cross Reactivity Human
Host Species Mouse
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary
Immunogen Human recombinant full length Pds1 protein
Isotype IgG2a kappa

Provide accurate, reproducible results with the Thermo Scientific™ Pds1 Ab-1, Mouse Monoclonal Antibody.

Pds1 is an anaphase inhibitor and plays important role in DNA damage and spindle check point pathways. Pds1 inhibits sister chromatid separation by binding and inhibiting Esp1, cystein protease that causes cleavage of the cohesin Scc1 that binds the sister chromatids together. Pds1 is responsible for targeting of Esp1 to nucleus and its binding to the spindle. Degradation of Pds1 occurs shortly before anaphase, which liberates Esp1 and is a prerequisite for anaphase entry. Pds1 is targeted for degradation by ubiquitination mediated by cyclosome/anaphase-promoting complex (APC) functioning as a ubiquitin ligase. In response to DNA damage Chk1 phosphorylates Pds1 to stabilize it against the APC mediated destruction, hence preventing the entry of such a cell into anaphase.

Host Species: Mouse

Clone: DCS-280

Isotype: IgG2a/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Human recombinant full-length Pds1 protein

Molecular Weight: 42kDa

Positive Control: HeLa cells, Tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not verified)

Note:

USA: RUO; Int'l: RUO