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Thermo Scientific™ Lab Vision™ Pds1 Ab-1, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ Pds1 Ab-1, Mouse Monoclonal Antibody.

$277.39 - $1,411.39

Specifications

Antigen Pds1 Ab-1
Clone DCS-280
Applications Immunohistochemistry (Paraffin),Western Blotting,Immunohistochemistry (Paraffin),Western Blotting
Classification Monoclonal
Conjugate Unlabeled
View More Specs


Products ${productFamilyLength}
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
MS1511P Thermo Scientific™ Lab Vision™
MS1511P
Purified Ab with BSA and Azide 1mL Each for $1,298.84
MS1511P0 Thermo Scientific™ Lab Vision™
MS1511P0
Purified Ab with BSA and Azide 100μL Each for $277.39
MS1511P1 Thermo Scientific™ Lab Vision™
MS1511P1
Purified Ab with BSA and Azide 500μL Each for $769.37
MS1511P1ABX Thermo Scientific™ Lab Vision™
MS1511P1ABX
Ab without BSA/Azide (Frozen) 100μL Each for $849.18
MS1511PABX Thermo Scientific™ Lab Vision™
MS1511PABX
Ab without BSA/Azide (Frozen) 200μL Each for $1,411.39
MS1511R7 Thermo Scientific™ Lab Vision™
MS1511R7
Ready-to-use for IHC (UVLP) 7mL Each for $671.78
Specifications

Description

Provide accurate, reproducible results with the Thermo Scientific™ Pds1 Ab-1, Mouse Monoclonal Antibody.

Pds1 is an anaphase inhibitor and plays important role in DNA damage and spindle check point pathways. Pds1 inhibits sister chromatid separation by binding and inhibiting Esp1, cystein protease that causes cleavage of the cohesin Scc1 that binds the sister chromatids together. Pds1 is responsible for targeting of Esp1 to nucleus and its binding to the spindle. Degradation of Pds1 occurs shortly before anaphase, which liberates Esp1 and is a prerequisite for anaphase entry. Pds1 is targeted for degradation by ubiquitination mediated by cyclosome/anaphase-promoting complex (APC) functioning as a ubiquitin ligase. In response to DNA damage Chk1 phosphorylates Pds1 to stabilize it against the APC mediated destruction, hence preventing the entry of such a cell into anaphase.

Host Species: Mouse

Clone: DCS-280

Isotype: IgG2a/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Human recombinant full-length Pds1 protein

Molecular Weight: 42kDa

Positive Control: HeLa cells, Tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not verified)

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Pds1 Ab-1
Immunohistochemistry (Paraffin),Western Blotting,Immunohistochemistry (Paraffin),Western Blotting
Unlabeled
Murine
Cancer and Tumor Biology
Human recombinant full length Pds1 protein
DCS-280
Monoclonal
Human
RUO
Primary
IgG2a kappa