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SpecificationsDescription & Specifications
Inhibitor, Enzyme; Tocris; PD 98059; MEK inhibitor; Molecular wt: 267.28; CAS Number: 167869-21-8; Formula: C16H13NO3; Purity:>98; 50mgInhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™.
- Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
- Formula: C16H13NO3
- CAS Number: 167869-21-8
- Solubility: Soluble to 25mM in DMSO and to 5mM in ethanol
- Purity: >98