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Tocris™ PD 98059

MEK inhibitor

Manufacturer: tocris™  RDS121310

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For Research Use Only

Catalog No. 121310

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Description & Specifications


Product Type PD 98059
Inhibitors PD 98059
Purity >98
Molecular Weight 267.28
Quantity 10mg

Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™.

  • Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
  • Formula: C16H13NO3
  • CAS Number: 167869-21-8
  • Solubility: Soluble to 25mM in DMSO and to 5mM in ethanol
  • Purity: >98