missing translation for 'onlineSavingsMsg'
Learn More
Please login to your online account to display your discounted pricing

Tocris™ PD 98059

MEK inhibitor

$84.73 - $762.58

Specifications

Product Type PD 98059
Inhibitors PD 98059
Molecular Weight 267.28
Purity >98
View More Specs

Disclaimers:

For Research Use Only



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
12131 Tocris™
RDS12131
1mg Each for $84.73
121310 Tocris™
RDS121310
10mg Each for $181.19
121350R Tocris™
RDS121350
50mg Each for $762.58
Specifications

Description

Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™.
  • Chemical Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
  • Formula: C16H13NO3
  • CAS Number: 167869-21-8
  • Solubility: Soluble to 25mM in DMSO and to 5mM in ethanol
  • Purity: >98
Description & Specifications

Specifications

PD 98059
PD 98059
267.28
>98