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Pax5 Rat anti-Human, Mouse, Clone: 1H9, eBioscience™

Rat Monoclonal Antibody

$143.88 - $341.88

Specifications

Antigen Pax5
Clone 1H9
Host Species Rat
Applications Immunohistochemistry (Frozen),Immunoprecipitation,Western Blot
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013865 Life Technologies
LS14991880
25μg Each for $143.88
5013866 Life Technologies
LS14991882
100μg Each for $341.88
Specifications

Description

The monoclonal antibody 1H9 recognizes both mouse and human Pax5. Pax5, also known as BSAP (B cell specific activator protein), is a member of the paired box (pax) family of transcription factors. Pax5 is the only member of the pax family of transcription factors that is expressed in hematopoietic cells. During embryogenesis, Pax5 is transiently expressed in the brain of mice and in the mesencephalon and spinal cord of humans. Its expression is upregulated early in B cell development at the time of B cell commitment and is maintained throughout most subsequent stages. Suppression of Pax5 is essential for expression of Blimp-1 and the terminal differentiation of plasma cells. In the spleen, expression of Pax5 is higher in marginal zone B cells (B220+ CD21high CD23low) than in other B cells, especially the transition 1 stage (B220+ CD21- CD23-). In addition to its role in B cell development, Pax5 also affects VH-DJH heavy chain recombination as well as influencing the expression of many other B and non-B cell related proteins. Pax5 expression is correlated with many neoplasms. In diffuse large B cell lymphomas (DLBCL) and non-Hodgkin lymphomas Pax5 is often mutated while in B-cell ALL, expression levels are high. Additionally, translocation with elastin, IGH, ETV6, FOXP1, and EVI3 have been identified.

eBioscience recommends that the Foxp3 Buffers (cat. 00-5521) be used for optimal results when using this antibody for intracellular staining and flow cytometric analysis.
Description & Specifications

Specifications

Pax5
Rat
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
1H9
Immunohistochemistry (Frozen),Immunoprecipitation,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL