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Pax5 Rat anti-Human, Mouse, Clone: 1H9, eBioscience™

Rat Monoclonal Antibody

$158.05 - $375.55

Specifications

Antigen Pax5
Clone 1H9
Host Species Rat
Species Reactivity Human, Mouse
Applications Immunohistochemistry (Frozen)
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013865

 
affymetrix
14-9918-80
25μg Each for $158.05

5013866

 
affymetrix
14-9918-82
100μg Each for $375.55
Description & Specifications

Specifications

Antigen Pax5
Clone 1H9
Host Species Rat
Species Reactivity Human, Mouse
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 1H9 recognizes both mouse and human Pax5. Pax5, also known as BSAP (B cell specific activator protein), is a member of the paired box (pax) family of transcription factors. Pax5 is the only member of the pax family of transcription factors that is expressed in hematopoietic cells. During embryogenesis, Pax5 is transiently expressed in the brain of mice and in the mesencephalon and spinal cord of humans. Its expression is upregulated early in B cell development at the time of B cell commitment and is maintained throughout most subsequent stages. Suppression of Pax5 is essential for expression of Blimp-1 and the terminal differentiation of plasma cells. In the spleen, expression of Pax5 is higher in marginal zone B cells (B220+ CD21high CD23low) than in other B cells, especially the transition 1 stage (B220+ CD21- CD23-). In addition to its role in B cell development, Pax5 also affects VH-DJH heavy chain recombination as well as influencing the expression of many other B and non-B cell related proteins. Pax5 expression is correlated with many neoplasms. In diffuse large B cell lymphomas (DLBCL) and non-Hodgkin lymphomas Pax5 is often mutated while in B-cell ALL, expression levels are high. Additionally, translocation with elastin, IGH, ETV6, FOXP1, and EVI3 have been identified.

eBioscience recommends that the Foxp3 Buffers (cat. 00-5521) be used for optimal results when using this antibody for intracellular staining and flow cytometric analysis.