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Alfa Aesar™ Paromomycin sulfate

Inhibits initiation and elongation during protein synthesis

$68.00 - $555.16

Chemical Identifiers

CAS 1263-89-4
Molecular Formula C23H47N5O18S
Molecular Weight (g/mol) 713.706
MDL Number MFCD00079278
InChI Key LJRDOKAZOAKLDU-JXDXLELXSA-N
PubChem CID 91972180
IUPAC Name (3S,5S,6S)-5-amino-2-(aminomethyl)-6-[(2R,4S,5S)-5-[(2R,5R,6R)-3,5-diamino-2-[(2S,3S,5S)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
SMILES C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
View More Specs

Products 3
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
AAJ6127403 View Documents Alfa Aesar™
J6127403
1g Each for $68.00
 
AAJ6127406 View Documents Alfa Aesar™
J6127406
5g Each for $166.55
 
AAJ6127414 View Documents Alfa Aesar™
J6127414
25g Each for $555.16
 
Description

Description

Applications
Paromomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Solubility
Soluble in water

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.
Specifications

Chemical Identifiers

1263-89-4
713.706
LJRDOKAZOAKLDU-JXDXLELXSA-N
(3S,5S,6S)-5-amino-2-(aminomethyl)-6-[(2R,4S,5S)-5-[(2R,5R,6R)-3,5-diamino-2-[(2S,3S,5S)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
C23H47N5O18S
MFCD00079278
91972180
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

Specifications

1263-89-4
MFCD00079278
14,7041
LJRDOKAZOAKLDU-JXDXLELXSA-N
(3S,5S,6S)-5-amino-2-(aminomethyl)-6-[(2R,4S,5S)-5-[(2R,5R,6R)-3,5-diamino-2-[(2S,3S,5S)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
91972180
Powder
1g
Paromomycin sulfate
C23H47N5O18S
5715182
Soluble in water
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
713.706
713.71
White
+51° (c=5 in Water)
Safety and Handling

Safety and Handling

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

GHS P Statement
P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

Warning

RTECSNumber : WK2320000