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Pan Cytokeratin (AE1/AE3) Mouse, eFluor 660, Clone: AE1/AE3, eBioscience™

Mouse Monoclonal Antibody

$216.05 - $549.55

Specifications

Antigen Pan Cytokeratin (AE1/AE3)
Clone AE1/AE3
Host Species Mouse
Gene Alias keratin, basic, acidic
Species Reactivity Canine, Human, Monkey, Mouse, Rabbit, Rhesus Ma
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124476

 
affymetrix
50900380
25μg Each for $216.05

501124477

 
affymetrix
50900382
100μg Each for $549.55
Description & Specifications

Specifications

Antigen Pan Cytokeratin (AE1/AE3)
Clone AE1/AE3
Host Species Mouse
Gene Alias keratin, basic, acidic
Species Reactivity Canine, Human, Monkey, Mouse, Rabbit, Rhesus Ma
Applications Immunocytochemistry
Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibodies AE1 and AE3 recognize many of the acidic and basic cytokeratin family members. Cytokeratins are intermediate filament proteins comprising one component of the cytoskeleton. There are two large families of cytokeratins, acidic and basic, but all contain the same basic domains (i.e. an alpha-helical core with an N- and C-terminal domain). The proteins are expressed in epithelial cells, but are developmentally regulated. Many tumors also express these proteins and their expression can help identify the origin of a neoplasm.

The AE3 monoclonal antibody recognizes the 65 to 67 triplet, 64, 59, 58, 56, 54 and 52kD proteins also known as cytokeratin 1, 2, 3, 4, 5, 6, 7, and 8 while the AE1 antibody recognizes 56.5, 54’, 50, 50’, 48, and 40kDa proteins (also known as CK10, 14, 15, 16 and 19). These antibodies can be used on a wide array of tissue samples from mouse, human, rat, primates (cynomolgus and rhesus), dog, cat, rabbit, and chicken.