Thermo Scientific™ Lab Vision™ p57 Kip2 Ab-7, Rabbit Polyclonal Antibody
Deliver accurate, reproducible results with the Thermo Scientific™ p57Kip2 Ab-7, Rabbit Polyclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ RB1637PABX
Deliver accurate, reproducible results with the Thermo Scientific™ p57Kip2 Ab-7, Rabbit Polyclonal Antibody.p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.
Host Species: Rabbit
Species Reactivity: Human, Cow and Mouse. Others not known.
Epitope: Near C-terminus
Immunogen: A synthetic peptide from human p57Kip2 protein
Molecular Weight: 57kDa
Positive Control: Colon CA or placenta
Cellular Localization: Nuclear
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting (Not suitable)
USA: RUO; Int'l: RUO
|Ab without BSA/Azide (Frozen)|
|A synthetic peptide from human p57superscriptKip2superscript protein|
|Cancer and Tumor Biology|