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Thermo Scientific™ Lab Vision™ p57 Kip2 Ab-7, Rabbit Polyclonal Antibody

Deliver accurate, reproducible results with the Thermo Scientific™ p57Kip2 Ab-7, Rabbit Polyclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  RB1637P1ABX

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Catalog No. RB1637P1ABX

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Description & Specifications


Antigen p57superscriptKip2superscript Ab-7
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Mouse
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Rabbit
Immunogen A synthetic peptide from human p57superscriptKip2superscript protein
Isotype IgG
Quantity 500μL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary
Monoclonal or Polyclonal Polyclonal
Target Species Bovine
Target Species Human
Target Species Murine

Deliver accurate, reproducible results with the Thermo Scientific™ p57Kip2 Ab-7, Rabbit Polyclonal Antibody.

p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Cow and Mouse. Others not known.

Epitope: Near C-terminus

Immunogen: A synthetic peptide from human p57Kip2 protein

Molecular Weight: 57kDa

Positive Control: Colon CA or placenta

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not suitable)


USA: RUO; Int'l: RUO