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Thermo Scientific™ Lab Vision™ p57 Kip2 Ab-7, Rabbit Polyclonal Antibody


Deliver accurate, reproducible results with the Thermo Scientific™ p57Kip2 Ab-7, Rabbit Polyclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  RB1637P1ABX

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Catalog No. RB1637P1ABX

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Description & Specifications

Specifications

Antigen p57superscriptKip2superscript Ab-7
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Mouse
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Rabbit
Immunogen A synthetic peptide from human p57superscriptKip2superscript protein
Isotype IgG
Quantity 500µL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary

Deliver accurate, reproducible results with the Thermo Scientific™ p57Kip2 Ab-7, Rabbit Polyclonal Antibody.

p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Cow and Mouse. Others not known.

Epitope: Near C-terminus

Immunogen: A synthetic peptide from human p57Kip2 protein

Molecular Weight: 57kDa

Positive Control: Colon CA or placenta

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not suitable)

Note:

USA: RUO; Int'l: RUO