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Thermo Scientific™ Lab Vision™ p21 WAF1 Ab-6, Mouse Monoclonal Antibody


Achieve accurate, reproducible results with the Thermo Scientific™ p21WAF1 Ab-6, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS454P1ABX

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Catalog No. MS454P1ABX

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Description & Specifications

Specifications

Format Concentrated
Applications Immunofluorescence
Applications Western Blotting
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Clone HJ21; same as WA-1
Cross Reactivity Human
Cross Reactivity Rat
Antigen p21WAF1 Ab-6
Host Species Mouse
Immunogen Human recombinant p21 protein
Classification Monoclonal
Conjugate Unlabeled
Research Discipline Cancer and Tumor Biology
Type Primary
Concentration 1mg/mL

Achieve accurate, reproducible results with the Thermo Scientific™ p21WAF1 Ab-6, Mouse Monoclonal Antibody.

p21WAF1/Cip1/Sdi1/Pic1 is a tumor suppressor protein. Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. It also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process.

Host Species: Mouse

Clone: HJ21; same as WA-1

Isotype: IgG1

Species Reactivity: Human and Rat. Others not known.

Epitope: Not determined

Immunogen: Human recombinant p21 protein

Molecular Weight: 21kDa

Positive Control: PC12, Ls174T or Raji cells

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Not suitable)
  • Flow Cytometry (Not Suitable)

Note:

USA: RUO; Int'l: RUO