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Thermo Scientific™ Lab Vision™ p21 WAF1 Ab-5, Mouse Monoclonal Antibody


Achieve accurate, reproducible results with the Thermo Scientific™ p21WAF1 Ab-5, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS387P1ABX

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Catalog No. MS387P1ABX

  • / Each
 

Description & Specifications

Specifications

Isotype IgG1
Immunogen Full length human recombinant p21 protein
Format Concentrated
Regulatory Status RUO
Host Species Mouse
Clone HZ52
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Rat
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Quantity 100µL
Antigen p21superscriptWAF1superscript Ab-5
Formulation Ab without BSA/Azide (Frozen)
Type Primary
Classification Monoclonal
Conjugate Unlabeled
Concentration 1mg/mL
Research Discipline Cancer and Tumor Biology

Achieve accurate, reproducible results with the Thermo Scientific™ p21WAF1 Ab-5, Mouse Monoclonal Antibody.

p21WAF1/Cip1/Sdi1/Pic1 is a tumor suppressor protein. Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. It also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process.

Host Species: Mouse

Clone: HZ52

Isotype: IgG1

Species Reactivity: Human, Cow, Mouse, and Rat. Others not known.

Epitope: Not determined

Immunogen: Full-length human recombinant p21 protein

Molecular Weight: 21kDa

Positive Control: Ls174T or Raji cells, Colon CA

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Immunoprecipitation
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO