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Thermo Scientific™ Lab Vision™ p170/p-Glycoprotein/MDR Ab-2, Mouse Monoclonal Antibody


Ensure accurate, reproducible results with the Thermo Scientific™ p170/p-Glycoprotein/MDR Ab-2, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS660P1ABX

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Catalog No. MS660P1ABX

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Description & Specifications

Specifications

Antigen p170/p-Glycoprotein/MDR Ab-2
Applications Immunofluorescence
Applications Western Blotting
Classification Monoclonal
Clone F4
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Hamster
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Human and hamster drug-resistant viable cells followed by crude plasma membranes
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary

Ensure accurate, reproducible results with the Thermo Scientific™ p170/p-Glycoprotein/MDR Ab-2, Mouse Monoclonal Antibody.

Multi-drug resistance(MDR) associated p-glycoprotein (p170) causes resistance to various drugs in a number of cancer patients. It exists in a soluble and membrane associated form. Soluble P-glycoprotein is detected in extracellular fluids of cancer patients, such as malignant ascites and serum. The Mr of soluble P-glycoprotein is the same as that of membrane bound P-glycoprotein.

Host Species: Mouse

Clone: F4

Isotype: IgG1

Species Reactivity: Human, Chinese Hamster. Does not react with mouse. Others not known.

Epitope: Extracellular amino terminal half. This epitope is resistant to formalin fixation and periodate oxidation and is different from those of other commonly known MAbs to p-glycoprotein, such as C219, JSB-1, and MRK16, which recognize an intracellular and extracellular epitope of p-glycoprotein, respectively.

Immunogen: Human and hamster drug-resistant viable cells followed by crude plasma membranes

Molecular Weight: 170kDa

Positive Control: Drug-resistant cells, Kidney or breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Flow Cytometry (Fixed cells only)

Note:

USA: RUO; Int'l: RUO