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Thermo Scientific™ Lab Vision™ p170/p-Glycoprotein/MDR Ab-2, Mouse Monoclonal Antibody


Ensure accurate, reproducible results with the Thermo Scientific™ p170/p-Glycoprotein/MDR Ab-2, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS660P1ABX

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Catalog No. MS660P1ABX

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Description & Specifications

Specifications

Applications Immunofluorescence
Applications Western Blotting
Regulatory Status RUO
Immunogen Human and hamster drug-resistant viable cells followed by crude plasma membranes
Antigen p170/p-Glycoprotein/MDR Ab-2
Host Species Mouse
Clone F4
Format Concentrated
Quantity 100µL
Cross Reactivity Hamster
Cross Reactivity Human
Isotype IgG1
Type Primary
Concentration 1mg/mL
Research Discipline Cancer and Tumor Biology
Conjugate Unlabeled
Classification Monoclonal

Ensure accurate, reproducible results with the Thermo Scientific™ p170/p-Glycoprotein/MDR Ab-2, Mouse Monoclonal Antibody.

Multi-drug resistance(MDR) associated p-glycoprotein (p170) causes resistance to various drugs in a number of cancer patients. It exists in a soluble and membrane associated form. Soluble P-glycoprotein is detected in extracellular fluids of cancer patients, such as malignant ascites and serum. The Mr of soluble P-glycoprotein is the same as that of membrane bound P-glycoprotein.

Host Species: Mouse

Clone: F4

Isotype: IgG1

Species Reactivity: Human, Chinese Hamster. Does not react with mouse. Others not known.

Epitope: Extracellular amino terminal half. This epitope is resistant to formalin fixation and periodate oxidation and is different from those of other commonly known MAbs to p-glycoprotein, such as C219, JSB-1, and MRK16, which recognize an intracellular and extracellular epitope of p-glycoprotein, respectively.

Immunogen: Human and hamster drug-resistant viable cells followed by crude plasma membranes

Molecular Weight: 170kDa

Positive Control: Drug-resistant cells, Kidney or breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Flow Cytometry (Fixed cells only)

Note:

USA: RUO; Int'l: RUO