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Thermo Scientific p14 ARF/p16β Ab-2, Mouse Monoclonal Antibody


Take advantage of a quality product that delivers accurate results with the Thermo Scientific™ p14ARF/p16β Ab-2, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific  MS850P1ABX

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Catalog No. MS850P1ABX

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Description & Specifications

Specifications

Antigen p14ARF/p16beta Ab-2
Quantity 100µL
Regulatory Status RUO
Applications Immunofluorescence
Applications Western Blotting
Immunogen Recombinant p14ARF protein
Host Species Mouse
Isotype IgG2a kappa
Cross Reactivity Human
Clone 14P02; same as DCS-240
Format Concentrated
Concentration 1mg/mL
Type Primary
Research Discipline Cell Cycle
Classification Monoclonal
Conjugate Unlabeled

Take advantage of a quality product that delivers accurate results with the Thermo Scientific™ p14ARF/p16β Ab-2, Mouse Monoclonal Antibody.

The INK4a-ARF locus encodes two unrelated proteins both of which function in tumor suppression. p14ARF arrests the cell cycle in a p53-dependent manner. p14ARF binds to mdm2 and promotes the rapid degradation of mdm2 protein required for mdm2 modification and concurrent p53 stabilization and accumulation. This interaction is mediated by the exon 1Β-encoded N-terminal domain of p14ARF and a C-terminal region of mdm2. Deletion of the ARF-INK4a locus simultaneously impairs both the INK4a-cyclin D/cdk4-RB and the ARF-mdm2-p53 pathways.

Host Species: Mouse

Clone: 14P02; same as DCS-240

Isotype: IgG1/κ

Species Reactivity: Human. Does not react with mouse and rat. Others not known.

Epitope: N-terminal

Immunogen: Recombinant p14ARF protein

Molecular Weight: 14kDa

Positive Control: HT-29 or HeLa cells

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Not optimum)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native verified)

Note:

USA: RUO; Int'l: RUO