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P-Cadherin Mouse anti-Human, Clone: 12H6, eBioscience™

Mouse Monoclonal Antibody

$117.48 - $262.68

Specifications

Antigen P-Cadherin
Clone 12H6
Host Species Murine
Applications Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Western Blot
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
50245616 Life Technologies
LS14987380
25μg Each for $117.48
50245617 Life Technologies
LS14987382
100μg Each for $262.68
Specifications

Description

The monoclonal antibody 12H6 recognizes human P-cadherin (placental-cadherin), a calcium dependent cell-cell adhesion protein. This 118kDa transmembrane protein was originally named due to its expression in mouse placental tissue. Unfortunately, it is not expressed in human placental tissue. The function of the molecule will depend on the associations with the specific member of the cytoplasmic catenin family (alpha, beta and gamma). The specific interaction defines the strength and signaling of the cell-cell interaction. Expression is less broad than E-cadherin; P-cadherin is restricted to the basal proliferative cell layer of stratified epithelia. During development expression is found in the proliferating tissues such as hair follicle keratinocytes and the growth regions in ductal mammary tissue. There is evidence that P-cadherin can be secreted from epithelial cells during the late stages of pregnancy. P-cadherin expression is associated with poor prognosis for breast cancer while reduced expression in melanomas and squamous cell carcinomas may also result in poor prognosis.
Description & Specifications

Specifications

P-Cadherin
Murine
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
12H6
Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL