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Tocris™ nTZDpa

Potent, selective PPARgamma partial agonist

$204.35 - $859.80

Specifications

Product Type nTZDpa
Inhibitors nTZDpa
Molecular Weight 428.33
Purity >98
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 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

215010R

 
tocris™
2150/10
10mg Each for $204.35

215050

 
tocris™
2150/50
50mg Each for $859.80
Description & Specifications

Specifications

Product Type nTZDpa
Inhibitors nTZDpa
Molecular Weight 428.33
Purity >98

Potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57nM); produces ∽25% maximum efficacy. Antagonizes full agonist activity by ∽60% (IC50 ∽ 285nM). Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo.

  • Chemical Name: 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
  • Formula: C22H15Cl2NO2S
  • CAS Number: 118414-59-8
  • Solubility: Soluble to 100mM in DMSO
  • Purity: >98