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Tocris™ nTZDpa

Potent, selective PPARgamma partial agonist

$212.74 - $886.68

Specifications

Product Type nTZDpa
Inhibitors nTZDpa
Molecular Weight 428.33
Purity >98
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Disclaimers:

For Research Use Only



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
215010R Tocris™
215010
10mg Each for $212.74
215050 Tocris™
215050
50mg Each for $886.68
Specifications

Description

Potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57nM); produces ∽25% maximum efficacy. Antagonizes full agonist activity by ∽60% (IC50 ∽ 285nM). Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo.
  • Chemical Name: 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
  • Formula: C22H15Cl2NO2S
  • CAS Number: 118414-59-8
  • Solubility: Soluble to 100mM in DMSO
  • Purity: >98
Description & Specifications

Specifications

nTZDpa
nTZDpa
428.33
>98