Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double stranded RNA (dsRNA) that is produced during the replicative life cycle of a majority of viruses. Poly(I:C) is known to induce type-1 interferon (IFN) through TLR3. Poly(I:C) directly binds to TLR3.
Species: Human, Mouse
Stimulation of TLR3 can be achieved with 10-100μg/mL
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.