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Thermo Scientific™ Lab Vision™ Notch-1 Ab-1, Mouse Monoclonal Antibody

Take advantage of a quality product that delivers accurate results with the Thermo Scientific™ Notch-1 Ab-1, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS1339P1ABX

 View more versions of this product

Catalog No. MS1339P1ABX


 

Specifications

Description

Take advantage of a quality product that delivers accurate results with the Thermo Scientific™ Notch-1 Ab-1, Mouse Monoclonal Antibody.

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals, which include notch-1. notch-2, notch-3, and notch-4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins δ and Serrate have been identified as ligands of notch-1. Mature notch proteins are heterodimeric receptors derived from the cleavage of notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm). Alteration of notch-1 signaling or expression may contribute to tumorigenesis.

Host Species: Mouse

Clone: A6

Isotype: IgG2b

Species Reactivity: Human and Mouse. Others not known.

Epitope: Ligand binding region

Immunogen: Recombinant protein encoding the ligand binding region of human Notch-1

Molecular Weight: 290kDa

Cellular Localization: Membrane

Recommended for:

  • Immunoprecipitation (Not verified)
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Notch-1 Ab-1
Monoclonal
1mg/mL
Human,Mouse
Murine
IgG2b
RUO
Primary
Human,Murine
Flow Cytometry
A6
Unlabeled
Concentrated
Recombinant protein encoding the ligand binding region of human Notch-1
100μL
Neuroscience
Monoclonal