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NF kappa B p65 Rabbit, Polyclonal, eBioscience™

Rabbit Polyclonal Antibody

$51.48 - $143.88

Specifications

Antigen NF kappa B p65
Host Species Rabbit
Gene Alias NFkB, NF kB
Applications Immunohistochemistry,Immunoprecipitation,Western Blot
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013524 Life Technologies
LS14673163
10μg Each for $51.48
5013525 Life Technologies
LS14673181
50μg Each for $143.88
Specifications

Description

The polyclonal antibody reacts with mouse, rat, and human NFkB p65; the antibody was raised against a peptide mapping to the carboxy terminus of human NFkB p65. Members of the rel/NFkB family of transcription factors are involved in the regulation of cellular responses, such as growth, development, and the inflammatory response. They share a structural motif known as the rel homology region (RHR), the C-terminal one third of which mediates protein dimerization (2, 6, 8). Complexes of p50 (NF-kB1) or p52 (NF-kB2) are generated through the processing of p105 and p100 precursors, respectively. These are usually associated with members of the Rel family (p65, c-Rel, Rel B). The homo- and heterodimer formed through combinations of NFkB/Rel proteins bind distinct kB sites to regulate the transcription of different genes (7, 9). In resting cells, NFkB is retained in the cytoplasm bound to inhibitory proteins of the IkB family. Degradation of IkB proteins occurs with cell activation, via of variety of signals, including inflammatory cytokines and bacterial lipopolysaccharides (LPS) as well as oxidative and fluid mechanical stress. This results in nuclear translocation of NFkB and the transcriptional gene activation of proinflammatory genes (1, 9). It has been suggested that NFkB plays a role in the development of numerous pathological states. Activation of NFkB induces gene programs leading to transcription of factors that promote inflammation, such as leukocyte adhesion molecules, cytokines, and chemokines. It is also thought that there are some substances with possible anti-inflammatory effects that are also NFkB regulated. There is some evidence indicating NFkB as a key factor in the pathophysiology of cardiac ischemia-reperfusion injury as well as the development of insulin dependent Diabetes Mellitus (4, 3).
Description & Specifications

Specifications

NF kappa B p65
NFkB, NF kB
RUO
Purified
Primary
200μg/mL rabbit polyclonal IgG in PBS, 0.1% sodium azide, 0.2% gelatin.
Rabbit
Immunohistochemistry,Immunoprecipitation,Western Blot
Unlabeled
Store at 2-8°C.
Polyclonal