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The 9.2.27 antibody has been reported to suppress melanoma tumor growth.Description & Specifications
DescriptionThis 9.2.27 monoclonal antibody reacts with human neural/glial antigen 2, which is also known as melanoma chondroitin sulfate proteoglycan (MCSP). This antigen is composed of a 250kDa N-linked glycoprotein and a >450kDa proteoglycan. NG2 is present on the surface of >90% of malignant melanomas in addition to some non-melanomic tumors. Moreover, NG2 is expressed on glioma cells, as well as on developing and adult oligodendrocyte precursor cells. Studies have demonstrated the involvement of this protein in tumor cell proliferation, adhesion, migration, and invasion. NG2 also functions as a coreceptor for alpha4beta1 integrin. Finally, expression of NG2 can be used as a prognostic marker for disorders such as acral letiginous melanoma and infantile acute myeloid leukemia.
The 9.2.27 antibody has been reported to suppress melanoma tumor growth.
|Neural / Glial Antigen 2 (NG2)|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Chondroitin Sulfate Proteoglycan, MCSP/melanoma chondroitin sulfate proteoglycan|
|Flow Cytometry,Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin)|
|Alexa Fluor 488|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|