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Nestin Mouse anti-Mouse, Rat, Clone: Rat-401 (Rat401 (4D4)), eBioscience™

Mouse Monoclonal Antibody

$129.05 - $346.55

Specifications

Antigen Nestin
Clone Rat-401 (Rat401 (4D4))
Host Species Mouse
Species Reactivity Mouse, Rat
Applications Immunocytochemistry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013205

 
affymetrix
14584380
25μg Each for $129.05

5013206

 
affymetrix
14584382
100μg Each for $346.55
Description & Specifications

Specifications

Antigen Nestin
Clone Rat-401 (Rat401 (4D4))
Host Species Mouse
Species Reactivity Mouse, Rat
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody Rat-401 recognizes mouse and rat nestin, a Class VI intermediate filament protein (>170 kDa) primarily expressed in neuroepithelial stem cells. Upon neural differentiation, expression is down-regulated and within the adult nervous system is limited to progenitor cells in the cortical subventricular zone, the hippocampal dentate gyrus, dorsal root ganglia satellite cells, and a subpopulation of Schwann cells. Nestin expression is also present in other progenitor cell populations such as pancreatic islet, angiogenic endothelial cells, and bone marrow mesenchymal stem cells. Nestin filaments require vimentin and desmin for assembly into heterodimers and polymers. Upon differentiation, Nestin-containing filaments are replaced by cell type specific intermediate filament proteins, such as GFAP.