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Musashi 2 Mouse anti-Human, Mouse, eFluor 660, Clone: C1, eBioscience™

Mouse Monoclonal Antibody

$146.52 - $355.08

Specifications

Antigen Musashi 2
Clone C1
Host Species Murine
Species Reactivity Human, Mouse
Applications Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Microscopy
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124514 Life Technologies
LS50967780
25μg Each for $146.52
501124515 Life Technologies
LS50967782
100μg Each for $355.08
Specifications

Description

The monoclonal antibody C1 recognizes human and mouse Musashi-2 (Msi2), a highly conserved RNA-binding protein. Musashi-2 contains two RNA-recognition domains and is expressed as one of two isoforms of 36 and 37kDa. Musashi 2 with its family member Musashi-1, are expressed at high levels in stem and tumor cells. During neural development, Musashi-2 is expressed in progenitor cells in the ventricular and subventricular zones, while postnatally, Musashi-2 expression is limited to multiple subsets of neurons and astrocytes in addition to adult stem cell populations. Functionally, Musashi-2 associates with Sox2 and is required for self-renewal of embryonic stem cells. Much like its role in maintaining stemness in neural progenitors, Musashi-2 is expressed in hematopoetic stem cells and plays a similar role in maintaining self-renewal. Musashi-2 has been found to be overexpressed in human myeloid leukemia and the levels of expression correlate with decreased survival. Musashi-2 may serve as a prognostic marker for acute myeloid leukemia (AML).
Description & Specifications

Specifications

Musashi 2
Murine
Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Microscopy
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL
C1
Human, Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer