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Musashi-1 is highly conserved and the 14H1 antibody also recognizes mouse and rat Musashi-1.Description & Specifications
DescriptionThis 14H1 monoclonal antibody recognizes human Musashi-1 (MSI-1), a 39kDa RNA binding protein. Musashi-1 is expressed in CNS stem and progenitor cells with decreased expression in differentiating cells. Musashi-1 functions as a translational repressor, directly regulating its target proteins, Numb and p21 (CIP1). Musashi-1 has been shown to be expressed in stem cells in a variety of other tissues such as the gut, stomach, mammary gland, and hair follicles. In addition to normal tissue expression, Musashi-1 expression has been identified in cells from several tumor types, mainly pulmonary and adenocarcinoma, as well as large and small cell carcinomas. Recently, expression of Musashi-1 in ischemic lesions following stroke provides evidence for neurogenesis as well as the role of Musashi-1 in regulating apoptosis.
Musashi-1 is highly conserved and the 14H1 antibody also recognizes mouse and rat Musashi-1.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Western Blot|
|Store at 2-8°C. Avoid repeated freeze/thaw cycles.|