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Thermo Scientific™ Lab Vision™ MUC-1 Ab-5, Hamster Monoclonal Antibody

Deliver accurate, reproducible results with the Thermo Scientific™ MUC-1 Ab-5, Hamster Monoclonal Antibody.

$351.92 - $1,752.98

Specifications

Antigen MUC-1 Ab-5
Clone MH1; same as CT2
Applications Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
Classification Monoclonal
Conjugate Unconjugated
View More Specs

Products 6
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
HM1630P View Documents Thermo Scientific™
HM1630P
Purified Ab with BSA and Azide 1mL Each for $1,631.86
 
HM1630P0 View Documents Thermo Scientific™
HM1630P0
Purified Ab with BSA and Azide 100μL Each for $351.92
 
HM1630P1 View Documents Thermo Scientific™
HM1630P1
Purified Ab with BSA and Azide 500μL Each for $981.78
 
HM1630P1ABX View Documents Thermo Scientific™
HM1630P1ABX
Ab without BSA/Azide (Frozen) 100μL Each for $1,074.47
 
HM1630PABX View Documents Thermo Scientific™
HM1630PABX
Ab without BSA/Azide (Frozen) 200μL Each for $1,752.98
 
HM1630R7 View Documents Thermo Scientific™
HM1630R7
Ready-to-use for IHC (UVLP) 7mL Each for $818.04
 
Description

Description

Deliver accurate, reproducible results with the Thermo Scientific™ MUC-1 Ab-5, Hamster Monoclonal Antibody.

Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other. Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1. Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind beta-catenin, GSK3beta and it associates with Grb2-SOS upon phosphorylation.

Host Species: Hamster

Clone: MH1 (CT2)

Isotype: IgG

Species Reactivity: Human and Mouse. Others not tested.

Epitope: aa 239-255

Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) from the cytoplasmic tail of MUC-1

Molecular Weight: 14-28kDa

Positive Control: MCF-7 cells; Breast CA

Cellular Localization: Cytoplasmic and membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

MUC-1 Ab-5
Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
Unconjugated
RUO
Primary
IgG
MH1; same as CT2
Monoclonal
Hamster
Cancer and Tumor Biology
A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1