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Thermo Scientific™ Lab Vision™ MUC-1 Ab-5, Hamster Monoclonal Antibody


Deliver accurate, reproducible results with the Thermo Scientific™ MUC-1 Ab-5, Hamster Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  HM1630PABX

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Catalog No. HM1630PABX

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Description & Specifications

Specifications

Antigen MUC-1 Ab-5
Applications Flow Cytometry
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone MH1; same as CT2
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Hamster
Immunogen A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1
Isotype IgG
Quantity 200µL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary

Deliver accurate, reproducible results with the Thermo Scientific™ MUC-1 Ab-5, Hamster Monoclonal Antibody.

Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other. Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1. Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind beta-catenin, GSK3beta and it associates with Grb2-SOS upon phosphorylation.

Host Species: Hamster

Clone: MH1 (CT2)

Isotype: IgG

Species Reactivity: Human and Mouse. Others not tested.

Epitope: aa 239-255

Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) from the cytoplasmic tail of MUC-1

Molecular Weight: 14-28kDa

Positive Control: MCF-7 cells; Breast CA

Cellular Localization: Cytoplasmic and membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO