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Thermo Scientific™ Lab Vision™ MUC-1 Ab-5, Hamster Monoclonal Antibody

Deliver accurate, reproducible results with the Thermo Scientific™ MUC-1 Ab-5, Hamster Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ HM1630P1ABX

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Catalog No. HM1630P1ABX


 

Specifications

Description

Deliver accurate, reproducible results with the Thermo Scientific™ MUC-1 Ab-5, Hamster Monoclonal Antibody.

Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other. Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1. Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind beta-catenin, GSK3beta and it associates with Grb2-SOS upon phosphorylation.

Host Species: Hamster

Clone: MH1 (CT2)

Isotype: IgG

Species Reactivity: Human and Mouse. Others not tested.

Epitope: aa 239-255

Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) from the cytoplasmic tail of MUC-1

Molecular Weight: 14-28kDa

Positive Control: MCF-7 cells; Breast CA

Cellular Localization: Cytoplasmic and membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

MUC-1 Ab-5
Monoclonal
1mg/mL
Human,Mouse
Ab without BSA/Azide (Frozen)
A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1
100μL
Cancer and Tumor Biology
Monoclonal
Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting
MH1; same as CT2
Unlabeled
Concentrated
Hamster
IgG
RUO
Primary
Human,Murine