Thermo Scientific™ Lab Vision™ MUC-1 Ab-5, Hamster Monoclonal Antibody
Deliver accurate, reproducible results with the Thermo Scientific™ MUC-1 Ab-5, Hamster Monoclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ HM1630P1ABX
Deliver accurate, reproducible results with the Thermo Scientific™ MUC-1 Ab-5, Hamster Monoclonal Antibody.Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other. Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1. Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind beta-catenin, GSK3beta and it associates with Grb2-SOS upon phosphorylation.
Host Species: Hamster
Clone: MH1 (CT2)
Species Reactivity: Human and Mouse. Others not tested.
Epitope: aa 239-255
Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) from the cytoplasmic tail of MUC-1
Molecular Weight: 14-28kDa
Positive Control: MCF-7 cells; Breast CA
Cellular Localization: Cytoplasmic and membrane
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Flow Cytometry
USA: RUO; Int'l: RUO
|Ab without BSA/Azide (Frozen)|
|A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1|
|Cancer and Tumor Biology|
|Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting|
|MH1; same as CT2|