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Thermo Scientific™ Lab Vision™ MSH2 (Mismatch Repair Protein 2) Ab-1, Mouse Monoclonal Antibody

Choose one marker in a comprehensive antibody portfolio that addresses all major disease states, ensuring the ideal tests are always available.

$245.63 - $992.24

Specifications

Antigen MSH2 (Mismatch Repair Protein 2) Ab-1
Clone 25D12
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Conjugate Unlabeled
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

MS1498R7

 
thermo scientific
MS-1498-R7
7mL Each for $647.61

MS1498S

 
thermo scientific™ lab vision™
MS-1498-S
1mL Each for $992.24

MS1498S0

 
thermo scientific™ lab vision™
MS-1498-S0
100µL Each for $245.63

MS1498S1

 
thermo scientific™ lab vision™
MS-1498-S1
500µL Each for $651.10
Description & Specifications

Specifications

Antigen MSH2 (Mismatch Repair Protein 2) Ab-1
Clone 25D12
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Conjugate Unlabeled
Host Species Mouse
Regulatory Status IVD
Research Discipline DNA Repair
Type Primary
Immunogen Recombinant human MSH2 protein

Choose one marker in a comprehensive antibody portfolio that addresses all major disease states, ensuring the ideal tests are always available with the Thermo Scientific™ MSH2 (Mismatch Repair Protein 2) Ab-1, Mouse Monoclonal Antibody.

Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSβ, which binds to insertion/deletion loops in DNA.

Host Species: Mouse

Clone: 25D12

Isotype: IgG1/κ

Species Reactivity: Human. Others not tested.

Immunogen: Recombinant human MSH2 protein

Molecular Weight: ∽102kDa

Positive Control: Tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)