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eBioscience™ Mouse TSLP, Recombinant Protein, Carrier-Free

Mouse Recombinant Protein

$1,680.55 - $3,812.05

Specifications

Name TSLP
Recombinant Yes
Conjugate Unlabeled
Purity >99%
Purification Method SDS-PAGE
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

509335

 
ebioscience™
34-8498-82
100μg Each for $1,680.55

509336

 
ebioscience™
34-8498-85
500μg Each for $3,812.05
Description & Specifications

Specifications

Name TSLP
Recombinant Yes
Conjugate Unlabeled
Purity >99%
Purification Method SDS-PAGE
Source Insect Cells
For Use With (Application) Cytokine Bioassays
Molecular Weight 15-22kDa on SDS-PAGE due to glycosylation.
Storage Requirements Store at less than or equal to -70°C.

Thymic Stromal Lymphopoietin (TSLP) is a member of the B cell-stimulating factor family. Originally identified from the conditioned medium of a mouse thymic stromal cell line that promoted B-cell development, TSLP is expressed in thymus, spleen, kidney, lung, and bone marrow. TSLP activity overlaps with that of IL-7, playing a key role in the development of B cells, as well as stimulating the growth of thymocytes and T cells. TSLP stimulates monocytes to produce T cell-attracting chemokines such as TARC (CCL17) and MDC (CCL22). TSLP also activates dendritic cell-primed CD4 T cells to produce Th2 cytokines, including IL-4, IL-5, IL-13, and TNF alpha. This hematopoietic cytokine binds to a heterodimeric receptor complex consisting of the IL-7R alpha chain (CD127) and the TSLP-specific chain (TSLPR). Binding induces activation of STAT3 and STAT5 via phosphorylation. Mouse TSLP shares approximately 43% amino acid sequence identity with human TSLP. Recombinant mouse TSLP is a 15.0 kDa protein consisting of 121 amino acid residues.