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eBioscience™ Mouse TGF beta 1, Recombinant Protein, Carrier-Free

Mouse Recombinant Protein

$1,661.88 - $5,542.68

Specifications

Structural Form TGFb1 was expressed in CHO cells.
Mature TGFb1 (ala279 - ser390; accession #BC001180) was
purified from the conditioned media.
Purity >95%
Purification Method SDS-PAGE
Molecular Weight Mature TGFb1 polypeptide has a predicted molecular mass of 12,794. On reducing SDS-PAGE the protein migrates as a 13kDa polypeptide and on non-reducing SDS page the cystine-linked homodimer migrates as a 25kDa protein.
Concentration 0.5mg/mL
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Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501123502 Life Technologies
LS34834285
500μg Each for $5,542.68
501129280 Life Technologies
LS34834282
100μg Each for $1,661.88
Specifications

Description

Mouse TGF beta 1 (Transforming Growth Factor beta 1) is a member of a superfamily of homologous, disulfide-linked, homodimeric proteins that regulate the proliferation and differentiation of normal and transformed cells. Human TGF beta 1 is a 25 kDa protein with each subunit containing 112 aa residues. TGF beta 1 is secreted from the many cell types in a complex with LAP (Latency Associated Peptide) and also with LTBP (latent TGF beta binding protein). Disassociation is thought to happen in the extracellular matrix via proteases and/or integrins. Regulatory T cells are a recently identified source of TGF beta 1 thought to be a key player in their suppressive functions. TGF beta 1 binds through TGF beta receptors (of which there is a large family). The protein is highly conserved across all mammalian species.
Description & Specifications

Specifications

TGFb1 was expressed in CHO cells.
Mature TGFb1 (ala279 - ser390; accession #BC001180) was
purified from the conditioned media.
SDS-PAGE
0.5mg/mL
BC001180
Sterile liquid; 0.1M Gly-HCl, pH 3.0. 0.22 µm
filtered.
Functional Assays, Cell Culture
Unlabeled
Mouse
TGF beta 1
>95%
Mature TGFb1 polypeptide has a predicted molecular mass of 12,794. On reducing SDS-PAGE the protein migrates as a 13kDa polypeptide and on non-reducing SDS page the cystine-linked homodimer migrates as a 25kDa protein.
CHO Cells
Less than 0.01ng/μg cytokine as determined by the LAL assay.
The ED50 of this protein, as measured by inhibition of IL-4 induced proliferation in HT-2 cells, is less than or equal to 40pg/mL. This corresponds to a specific activity of greater than or equal to 2.5 x 107 units/mg.
FA
RUO
Transforming growth factor beta-1
Yes