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eBioscience™ Mouse M-CSF, Recombinant Protein

Mouse Recombinant Protein

$66.00 - $183.48

Specifications

Name M-CSF
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE
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Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5018556 Life Technologies
LS14898362
5μg Each for $66.00
5018557 Life Technologies
LS14898380
25μg Each for $183.48
Specifications

Description

Macrophage colony-stimulating factor (M-CSF or CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization.

M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. The secreted protein is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex.
Description & Specifications

Specifications

M-CSF
Unlabeled
SDS-PAGE
Cytokine Bioassays
Store at less than or equal to -70°C.
Yes
>98%
Insect Cells
37.79kDa