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eBioscience™ Mouse M-CSF, Recombinant Protein

Mouse Recombinant Protein

$72.50 - $201.55

Specifications

Name M-CSF
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

5018556

 
ebioscience™
14898362
5μg Each for $72.50

5018557

 
ebioscience™
14898380
25μg Each for $201.55
Description & Specifications

Specifications

Name M-CSF
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE
Source Insect Cells
For Use With (Application) Cytokine Bioassays
Molecular Weight 37.79kDa
Storage Requirements Store at less than or equal to -70°C.

Macrophage colony-stimulating factor (M-CSF or CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization.

M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. The secreted protein is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex.