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eBioscience™ Mouse LIF, Recombinant Protein

Mouse Recombinant Protein

$130.68 - $341.88


Structural Form E. coli derived Ser24-Phe203 accession number NM_008501
Purity >98%
Purification Method SDS-PAGE
Molecular Weight 20kDa
Concentration 0.1mg/mL
View More Specs


For Research Use Only.

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Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501128870 Life Technologies
25μg Each for $341.88
5018530 Life Technologies
5μg Each for $130.68


Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
Description & Specifications


E. coli derived Ser24-Phe203 accession number NM_008501
Sterile liquid; phosphate-buffered saline with 0.05% Tween-20 and 1% BSA, 0.22μm filtered.
Cytokine Bioassays
leukocyte inhibitory factor, Leukemia inhibitory factor
E. coli
Less than 0.01ng/μg cytokine as determined by the LAL assay
Recombinant mouse LIF has been tested for induction of mIL-6 in the M1 cell line. The ED50 in this assay is 0.75-0.4ng/mL, which corresponds to a specific activity of 1.3 x 106 - 2.5 x 106 Units/mg. When used at 10ng/mL, this recombinant protein has also been found to support mouse embryonic stem cells in an undifferentiated state at same concentration.