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eBioscience™ Mouse IL-23, Recombinant Protein, Carrier-Free

Mouse Recombinant Protein

$3,043.55 - $9,133.55

Specifications

Name IL-23
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123500

 
ebioscience™
34823182
100μg Each for $3,043.55

509179

 
ebioscience™
34823185
500μg Each for $9,133.55
Description & Specifications

Specifications

Name IL-23
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE
Source Insect Cells
For Use With (Application) Cytokine Bioassays
Molecular Weight The heterodimer of p40, amino acids met 23-ser 355, cystine-linked to p19, amino acids leu 20-ala 196, has a predicted molecular mass of 55,616. On non-reducing SDS-PAGE the heterodimeric cystine-linked protein migrates as a 60kDa protein. The DTT reduced protein migrates as 43kDa and 21kDa polypeptides.
Storage Requirements Store at less than or equal to -70°C.

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN-γ. Mouse IL-23 does induce strong proliferation of memory T cells (but not naïve T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naïve and memory T cells, as compared to IL-12.