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Invitrogen™ Mouse TNF-alpha High Sensitivity ELISA

For the quantitative detection of mouse TNF-alpha.

Manufacturer:  Invitrogen™ LSBMS6001

 View more versions of this product

Catalog No. 501128692



Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to mouse IL-17
Biotin-Conjugate anti-mouse IL-17 monoclonal antibody
Streptavidin-HRP
Mouse IL-17 Standard lyophilized, 1ng/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

Mouse IL-17 mRNA is specifically expressed by activated alpha beta TCR + CD2-CD8-T-cells, a small subset with a potentially important role in immune regulation. IL-17 induces the secretion of IL-6, IL-8, PGE2, MCP-1 and G-CSF by adherent cells like fibroblasts, keratinocytes, epithelial and endothelial cells. IL-17 is also able to induce ICAM-1 surface expression of T-cells. IL-17 has been shown to support the growth of hemopoietic progenitors, it has stimulatory effects on granulopoiesis in mice.

IL-17 may affect osteoclastic resorption and thereby mediate bone destruction accompanying some inflammatory diseases. Astrocytes produce NO when stimulated by IL-17, which suggests a possible role for IL-17 in the inflammatory diseases of the CNS. Forced expression of murine IL-17 induces immune responses and multiorgan inflammation.

Interleukin-17 is involved in the regulation of hematopoiesis and its effects are dependent on the physiological/pathological status of the organism. IL-17 expression in airways is upregulated upon allergen exposure like in allergic asthma. Its crucial role in T-cell activation suggests that IL-17 is involved in the development of autoimmune arthritis.

Specifications

Specifications

Q62386
Biotin
16171
Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
96 tests
1.6pg/mL
50μL
Mouse
1 hr 20 min
IL-17A
Interleukin-17, IL-17A, CTLA8
9.1%
7.8-500 pg/mL
ELISA
Colorimetric Microplate Reader
ELISA
RUO
Cell culture supernatant, serum
Serum (50μL), Supernatants (50μL)
2-8°C
3 hr 10 min
Il17a
8.5%
HRP
Documents

For Research Use Only