The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
Assay Type: Solid Phase Sandwich ELISA
Sample Type/Volume Required: Cell Culture Supernates (50μL), Serum (50μL), EDTA Plasma (50μL), Heparin Plasma (50μL)
Specificity: Natural and recombinant mouse IL-17
Cross Reactivity: <50% cross-species reactivity observed with species tested. Cross-reactivity observed with 1 or more available related molecules.
|<50% cross-species reactivity observed with species tested. Cross-reactivity observed with 1 or more available related molecules|
|Cell Culture Supernates (50μL), Serum (50μL), EDTA Plasma (50μL), Heparin Plasma (50μL)|
|Sufficient materials to run ELISAs on at least two 96-well plates|
|Solid Phase Sandwich ELISA|
|Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma|
|Natural and recombinant mouse IL-17|