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eBioscience™ Mouse HMGB1, Recombinant Protein, Carrier-Free

Mouse Recombinant Protein

$1,825.55 - $4,566.05

Specifications

Name HMGB1
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

509225

 
ebioscience™
34-8401-85
500μg Each for $4,566.05

509224

 
ebioscience™
34840182
100μg Each for $1,825.55
Description & Specifications

Specifications

Name HMGB1
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE
Source E. coli
For Use With (Application) Cytokine Bioassays
Molecular Weight The protein contains an N-terminal His tag and has a predicted molecular mass of 27.6kDa.
Storage Requirements Store at less than or equal to -70°C.

High-mobility group box-1 (HMGB1) protein was originally described as a nuclear non-histone DNA binding chromosomal protein. However, recent studies indicate that damaged, necrotic cells liberate HMGB1 into the extracellular milieu where it functions as a proinflammatory cytokine. Mouse HMGB1 is expressed as a 215 amino acid single chain polypeptide containing three domains: two tandem-linked positively charged DNA-binding domains (HMG box A, aa 9-79; and box B, aa 89-162), and a negatively charged 30 aa C-terminal acidic tail region. Residues 28 - 44 and 180 - 185 contain a nuclear localization signal (NLS). The cytokine activity of HMGB1 is contained in the B box, while the A box is associated with the helix-loop-helix domain of transcription factors. HMGB1 acts both as an inflammatory mediator that promotes monocyte migration and cytokine secretion, as well as a mediator of T cell-dendritic cell interaction. HMGB1 is secreted and acts to transduce cellular signals through its high affinity receptor, RAGE and possibly, TLR2 and TLR4.