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Mouse anti-Tyrosinase, Clone: SPM360, Azide Free, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23477001MG

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For Research Use Only

Catalog No. NBP23477001

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Description & Specifications

Specifications

Host Species Mouse
Regulatory Status RUO
Isotype IgG2a, κ
Format Purified
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Immunogen Recombinant tyrosinase protein
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Antigen Tyrosinase
Concentration 1mg/mL
Cross Reactivity Human
Reconstitution Protein A purified
Primary or Secondary Primary
Gene Accession No. P14679
Formulation 10mM PBS. Does not contain BSA. Azide Free.
Monoclonal or Polyclonal Monoclonal
Test Specificity Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Conjugate Unlabeled
Purification Method Purified
Clone SPM360
Quantity 0.1mg
Gene ID (Entrez) 7299