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Mouse anti-Tyrosinase, Clone: SPM360, Azide Free, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23477001MG

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 Disclaimers

For Research Use Only

Catalog No. NBP23477001

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Description & Specifications

Specifications

Antigen Tyrosinase
Format Purified
Gene Accession No. P14679
Host Species Mouse
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Immunogen Recombinant tyrosinase protein
Isotype IgG2a, κ
Regulatory Status RUO
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Primary or Secondary Primary
Reconstitution Protein A purified
Concentration 1mg/mL
Cross Reactivity Human
Formulation 10mM PBS. Does not contain BSA. Azide Free.
Purification Method Purified
Quantity 0.1mg
Monoclonal or Polyclonal Monoclonal
Gene ID (Entrez) 7299
Test Specificity Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Clone SPM360
Conjugate Unlabeled