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Mouse anti-Tyrosinase, Clone: SPM360, Azide Free, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23477002MG

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 Disclaimers

For Research Use Only

Catalog No. NBP23477002

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Description & Specifications

Specifications

Antigen Tyrosinase
Formulation 10mM PBS. Does not contain BSA. Azide Free.
Host Species Mouse
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Immunogen Recombinant tyrosinase protein
Purification Method Purified
Quantity 0.2mg
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Test Specificity Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Reconstitution Protein A purified
Cross Reactivity Human
Format Purified
Gene Accession No. P14679
Isotype IgG2a, κ
Regulatory Status RUO
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Gene ID (Entrez) 7299
Clone SPM360
Concentration 1mg/mL
Conjugate Unlabeled