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Mouse anti-Tyrosinase, Clone: SPM360, Azide Free, Novus Biologicals™

Manufacturer:  Novus Biologicals Canada NBP23477002MG

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Catalog No. NBP23477002


 

Disclaimers:

For Research Use Only


Specifications Description & Specifications

Specifications

Tyrosinase
SPM360
Unlabeled
10mM PBS. Does not contain BSA. Azide Free.
Murine
IgG2a, κ
0.2mg
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Monoclonal
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Human
ELISA,Flow Cytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Frozen),Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
1mg/mL
Purified
P14679
Recombinant tyrosinase protein
Purified
RUO
Primary
7299
Protein A purified