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Mouse anti-Tyrosinase, Clone: SPM360, Azide Free, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23477002MG

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 Disclaimers

For Research Use Only

Catalog No. NBP23477002

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Description & Specifications

Specifications

Immunogen Recombinant tyrosinase protein
Quantity 0.2mg
Cross Reactivity Human
Formulation 10mM PBS. Does not contain BSA. Azide Free.
Host Species Mouse
Reconstitution Protein A purified
Purification Method Purified
Antigen Tyrosinase
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Test Specificity Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone SPM360
Gene Accession No. P14679
Conjugate Unlabeled
Format Purified
Isotype IgG2a, κ
Regulatory Status RUO
Gene ID (Entrez) 7299
Concentration 1mg/mL