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Mouse anti-TFF1/pS2, Clone: SPM573, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23290010ML

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 Disclaimers

For Research Use Only

Catalog No. NBP23290010

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Description & Specifications

Specifications

Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen TFF1/pS2
Format Purified
Storage Requirements Store at 4°C. Do not freeze.
Host Species Mouse
Cross Reactivity Human
Cross Reactivity Primate
Concentration 0.2mg/mL
Formulation PBS with 0.05% BSA.
Quantity 1.0mL
Clone SPM573
Gene Accession No. P04155
Reconstitution Protein A purified
Purification Method Purified
Regulatory Status RUO
Test Specificity It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy. Reacts to Cynomolgus Monkey.
Isotype IgG1, κ
Immunogen Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2.
Gene ID (Entrez) 7031