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Mouse anti-TFF1/pS2, Clone: SPM573, Azide Free, Novus Biologicals™

Manufacturer:  Novus Biologicals Canada NBP23480602MG

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Catalog No. NBP23480602


 

Disclaimers:

For Research Use Only


Specifications Description & Specifications

Specifications

TFF1/pS2
SPM573
Unlabeled
10mM PBS. Does not contain BSA. Azide Free.
Murine
IgG1, κ
0.2mg
Store at -20 to -80°C. Avoid freeze-thaw cycles.
Monoclonal
It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy. Reacts to Cynomolgus Monkey.
Human,Primate
ELISA,Flow Cytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Frozen),Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
1mg/mL
Purified
P04155
Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2.
Purified
RUO
Primary
7031
Protein A purified