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Mouse anti-SUMO2/3, Clone: SPM572, Azide Free, Novus Biologicals™

Manufacturer:  Novus Biologicals Canada NBP23443101MG

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Catalog No. NBP23443101


 

Disclaimers:

For Research Use Only


Specifications Description & Specifications

Specifications

SUMO2/3
SPM572
Unlabeled
10mM PBS. Does not contain BSA. Azide Free.
Murine
IgG1, κ
0.1mg
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Monoclonal
This MAb reacts with both SUMO-2 and SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease. Expected to show broad species reactivity.
All,Human,Murine,Rat
ELISA,Flow Cytometry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Frozen),Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blot
1mg/mL
Purified
P55854
Recombinant human SUMO2 protein
Purified
RUO
Primary
6613
Protein A purified