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Mouse anti-SUMO2/3, Clone: SM23/496, Novus Biologicals™


Manufacturer: novus biologicals canada  NBP23429201ML

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 Disclaimers

For Research Use Only

Catalog No. NBP23429201

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Description & Specifications

Specifications

Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Host Species Mouse
Quantity 0.1mL
Monoclonal or Polyclonal Monoclonal
Cross Reactivity Human
Antigen SUMO2/3
Format Purified
Formulation PBS with 0.05% BSA.
Immunogen Recombinant human SUMO2 protein
Purification Method Purified
Regulatory Status RUO
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Primary or Secondary Primary
Reconstitution Protein A purified
Gene Accession No. P61956
Isotype IgG1, κ
Test Specificity This MAb reacts with both SUMO-2 and SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease. Shows broad species reactivity.
Clone SM23/496
Concentration 0.2mg/mL
Gene ID (Entrez) 6613
Conjugate Unlabeled