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Mouse anti-SUMO1, Clone: SPM571, Novus Biologicals™

Manufacturer: novus biologicals canada  NBP23290210ML

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For Research Use Only

Catalog No. NBP23290210

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Description & Specifications


Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Primary or Secondary Primary
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Regulatory Status RUO
Antigen SUMO1
Formulation PBS with 0.05% BSA.
Monoclonal or Polyclonal Monoclonal
Gene Accession No. P63165
Conjugate Unlabeled
Concentration 0.2mg/mL
Gene ID (Entrez) 7341
Isotype IgG1, κ
Clone SPM571
Immunogen Recombinant human SUMO1 protein
Quantity 1.0mL
Host Species Mouse
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Format Purified
Reconstitution Protein A purified
Purification Method Purified
Test Specificity This MAb is specific to SUMO-1 and shows no cross-reaction with either SUMO-2 or SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1 protein localizes to the nuclear membrane. Shows broad species reactivity.