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Mouse anti-Renal Cell Carcinoma (gp200), Clone: 66.4.C2 (PN-15), Novus Biologicals™


Manufacturer: novus biologicals canada  NBP21519901MG

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 Disclaimers

For Research Use Only

Catalog No. NBP21519901

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Description & Specifications

Specifications

Primary or Secondary Primary
Applications ELISA
Applications Flow Cytometry
Applications Immunocytochemistry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Quantity 0.1mg
Conjugate Unlabeled
Gene ID (Entrez) 4065
Monoclonal or Polyclonal Monoclonal
Clone 66.4.C2 (PN-15)
Purification Method Purified
Gene Accession No. Q16790
Concentration 0.2mg/mL
Isotype IgG2b, κ
Cross Reactivity Equine
Cross Reactivity Human
Format Purified
Regulatory Status RUO
Antigen Renal Cell Carcinoma (gp200)
Storage Requirements Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Host Species Mouse
Test Specificity Recognizes a glycoprotein of ∽200kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.
Immunogen Fresh
Formulation PBS with 0.05% BSA. Protein G purified.